ABSTRACT
The objective of this study was to investigate the antibacterial and antioxidant activities of the methanol leaf extract of Maerua crassifolia, an important medicinal plant used in Nigeria. The antibacterial properties of the methanol extract were studied against clinically important bacteria viz; Staphylococcus aureus, Shigella spp., Salmonella typhi, Bacillus subtilis and Escherichia coli by disc diffusion method. The free radical scavenging potential of the extract was assessed by measuring its capability for scavenging 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical. The methanol leaf extract of Maerua crassifolia at the concentration of 12.5-150 μg/ml, showed significant activity against all the tested organisms. The observed antioxidant activity of the leaf extract suggests that the extract is a potential source of natural antioxidant and could be useful in the treatment of diseases.
ABSTRACT
OBJECTIVE@#To investigate the antimalarial activity of ethanol extract of Aspilia africana (A. africana) leaf.@*METHODS@#The ethanol extract of A. africana leaf (100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei (P. berghei) in mice both in early and established models of antimalarial studies.@*RESULTS@#The leaf extract exhibited significant (P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug, chloroquine (10 mg/kg).@*CONCLUSIONS@#The findings show that ethanol extract of A. africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.